### When do you use Cockroft Gault?

## When do you use Cockroft Gault?

The Cockcroft-Gault formula for estimating creatinine clearance (CrCl) should be used routinely as a simple means to provide a reliable approximation of residual renal function in all patients with CKD. The formulas are as follows: CrCl (male) = ([140-age] × weight in kg)/(serum creatinine × 72)

### What is the formula for creatinine clearance?

Creatinine Clearance Calculator Est. Creatinine Clearance = [[140 – age(yr)]*weight(kg)]/[72*serum Cr(mg/dL)] (multiply by 0.85 for women). The results you receive from this tool are for informational purposes only and should not be the basis of your medical decision making.

#### Should we continue to use the Cockcroft-Gault formula?

Conclusions: CG still has an interest in screening the decline in renal function in subjects with normal SCr who are at risk, such as diabetics and stage 1 and 2 CKD patients, as well as healthy subjects enrolled in clinical trials and pharmacokinetic studies.

**What is the formula for eGFR?**

Race | Sex | Equation (age in years for ≥ 18) |
---|---|---|

White or other | Female | GFR = 144 × (Scr/61.9)-0.329 × (0.993)Age |

White or other | Female | GFR = 144 × (Scr/61.9)-1
Calculate estimated GFR (eGFR) from serum creatinine levels to assess kidney function. Use of any serum creatinine-based estimate requires that kidney function be at a steady state. eGFR should be used with caution in acutely ill or hospitalized patients who may exhibit rapidly changing kidney function. ## When do you not use Cockcroft-Gault equation?The Cockcroft-Gault (CG) formula is provided on this website for research purposes only. It should not be used for drug dosing or to estimate GFR. The best way to determine drug dosing is with the CKD-EPI Creatinine Equation (2009) or the MDRD Study. Both have been shown to be more accurate than the CG formula. ## Why is CKD-EPI better than Mdrd?The CKD-EPI equation, a newly developed equation for estimating GFR, has been proposed to be more accurate than the MDRD equation, especially when GFR is high. Moreover, it shows less bias, improved precision, and greater accuracy[8]. ## What is the normal range of eGFR?A normal eGFR is 60 or more. If your eGFR is less than 60 for three months or more, your kidneys may not be working well. Use this chart to see what your eGFR may mean.
Multiple studies have compared the equations for their impact on drug dosages. In the few studies that compared estimated GFR from the various equations to measured GFR, the studies have shown that the MDRD Study or CKD-EPI equation had greater concordance with measured GFR than the Cockcroft-Gault.
Background/aims: Although the National Kidney Disease Education Program recommends use of the modification of diet in renal disease (MDRD) formula to estimate the glomerular filtration rate (GFR), most drug-dosing recommendations and clinical practices employ the Cockcroft-Gault (CG) formula. ## Is the Cockcroft Gault equation still used for drug dosing?Creatinine clearance is still used as the standard for drug dosing, instead of GFR. The Cockcroft-Gault Equation may be inaccurate depending on a patient’s body weight and BMI; by providing additional height, we can calculate BMI and provide a modified estimate and range. Please fill out required fields. ## How is CrCL calculated according to the Cockcroft-Gault equation?Creatinine Clearance (Cockcroft-Gault Equation) Calculates CrCl according to the Cockcroft-Gault equation. For use in patients with stable renal function to estimate creatinine clearance. Can be used to estimate kidney function for CKD staging. Can be used to adjust or discontinue medications based on kidney function.
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