What is the action of morphine in myocardial infarction?

What is the action of morphine in myocardial infarction?

As a potent opioid, morphine has seemed to be the ideal analgesic. It has innate hemodynamic effects that are beneficial during MI. It decreases heart rate, blood pressure, and venous return, and it may also stimulate local histamine-mediated processes. Theoretically, this reduces myocardial oxygen demand.

Why is morphine used for cardiac pain?

Chest pain is the most common symptom of patients who present with ischemic heart disease. Morphine has traditionally been the drug of choice for managing chest pain in acute coronary syndrome (ACS) due to its high analgesic potency, though its physiological effects are poorly understood.

Why is morphine used for acute MI?

With potent analgesic properties, perceived hemodynamic benefits and limited alternatives, morphine is the analgesic mainstay for patients with nitrate resistant chest pain due to acute Myocardial Infarction (MI).

Why is morphine preferred in ACS?

The administration of morphine is widely accepted as a treatment for chest pain in the setting of an acute coronary syndrome (ACS). Its use is recommended based on assumptions that adequate pain control modulates sympathetic nervous system activation and therefore decreasing myocardial oxygen demand.

Why is aspirin given for MI?

Long-term aspirin therapy reduces the yearly risk of serious vascular events (nonfatal myocardial infarction, nonfatal stroke, or vascular death), which corresponds to an absolute reduction of nonfatal events and to a smaller, but still definite, reduction in vascular death.

Why is morphine IV used in the management of chest pain?

Morphine also has an obvious sedative effect. In theory, morphine can reduce acute ischemic chest pain patients’ sympathetic response and decrease systemic vascular resistance and heart rate, improve the balance of myocardial metabolic requirement and supply through pain relief.

What are four cardiovascular conditions that may lead to heart failure?

The most common conditions that can lead to heart failure are coronary artery disease, high blood pressure and previous heart attack. If you’ve been diagnosed with one of these conditions, it’s critical that you manage it carefully to help prevent the onset of heart failure.

Why is oxygen given for MI?

The rationale behind oxygen therapy is to increase oxygen delivery to the ischemic myocardium and thereby limit infarct size and subsequent complications. The basis for this practice is limited to experimental laboratory data and small clinical studies.

Is morphine used in ACS?

Background: Morphine is widely used for pain control in patients with acute coronary syndrome (ACS).

What is the action of aspirin so important?

Aspirin causes several different effects in the body, mainly the reduction of inflammation, analgesia (relief of pain), the prevention of clotting, and the reduction of fever. Much of this is believed to be due to decreased production of prostaglandins and TXA2.

How much aspirin do you give for MI?

The appropriate dose must be at least 160 mg/day. The lowest dose to prevent recurrent MI or death in patients with stable coronary artery disease (CAD) is 75 mg/day. In acute MI the lowest dose is 160 mg/day.

What is the mechanism of action of morphine?

Morphine can decrease the heart rate, blood pressure, and venous return. Morphine can also stimulate local histamine-mediated processes.[4]  In theory, the combination of these can reduce myocardial oxygen demand. Mechanism of Action Morphine is considered the classic opioid analgesic with which other painkillers are compared.

What are the FDA approved uses of morphine?

Indications FDA-approved usage of morphine sulfate includes moderate to severe pain that may be acute or chronic.  Most commonly used in pain management, morphine provides significant relief to patients afflicted with pain. 

Are there any drugs that have cardiotonic effects?

Drugs with established cardiotonic effects include cardiac glycosides, beta 1-adrenergic agents, glucagon, histamine and the methylxanthines. New agents discussed are prenalterol, beta 2- and alpha-adrenergic drugs, amrinone and sulmazole. Prenalterol is a beta 1-adrenergic agent.

How does morphine decrease the heart rate and blood pressure?

Morphine can decrease the heart rate, blood pressure, and venous return. Morphine can also stimulate local histamine-mediated processes. [4] In theory, the combination of these can reduce myocardial oxygen demand.

What is the action of morphine in myocardial infarction? As a potent opioid, morphine has seemed to be the ideal analgesic. It has innate hemodynamic effects that are beneficial during MI. It decreases heart rate, blood pressure, and venous return, and it may also stimulate local histamine-mediated processes. Theoretically, this reduces myocardial oxygen demand. Why…