What is an idiosyncratic response?

Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect.

What is an example of an idiosyncratic reaction?

Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.

What is idiosyncrasy of drug?

Abstract. “Drug idiosyncrasy” refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.

What is Type B adverse reaction?

Type B Reactions Type B (bizarre) reactions are novel responses that are not expected from the known pharmacological actions of the drug. These are less common, and so may only be discovered for the first time after a drug has already been made available for general use.

What is an idiosyncratic type?

Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. A minimal amount of drug will cause an immune response, but it is suspected that at a low enough concentration, a drug will be less likely to initiate an immune response.

What are idiosyncratic side effects?

Idiosyncratic drug reactions may be defined as adverse effects that cannot be explained by the known mechanisms of action of the offending agent, do not occur at any dose in most patients, and develop mostly unpredictably in susceptible individuals only.

What is idiosyncratic toxicity?

Idiosyncratic toxicity can occur when a convergence of risk factors, including drug exposure, tips the risk-benefit balance away from benefit and toward risk.

What is Type D adverse drug reaction?

Type D: Time related reactions, i.e. due to prolonged use in a drug which doesn’t tend to accumulate (eg. tardive dyskinesia from antipsychotics) Type E: Withdrawal reactions, i.e. the undesired effects of ceasing the drug (for example, opiate withdrawal)

What is the most common type of adverse reaction?

The ten most common ADRs were constipation, nausea +/- vomiting, fatigue, alopecia, drowsiness, myelosuppression, skin reactions, anorexia, mucositis and diarrhoea. These ADRs have high-documented incidence rates and were also the ten most predictable ADRs in this study.

How do you use idiosyncratic in a sentence?

Examples of ‘idiosyncratic’ in a sentence idiosyncratic

The organisers of the festival pride themselves on their idiosyncratic approach.
But his determinedly idiosyncratic approach was evident quite early on.
Yet his book is also idiosyncratic both in style and in some points of detail.

When an abnormal or unusual reaction to a drug?

Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. This is not to be mistaken with idiopathic, which implies that the cause is not known.

What is an idiosyncratic response? Idiosyncrasy is an abnormal reactivity to a chemical that is peculiar to a given individual. It could be: An abnormally exaggerated response, or an abnormal lack of response. A response unusual because it requires an unusually small or unusually large dose. An extension of the normal physiological drug effect. What…