What is allopurinol hypersensitivity syndrome?

Over 60% of patients had received allopurinol for asymptomatic hyperuricemia. Hallmarks of this hypersensitivity syndrome include a prolonged illness initially manifested by fever, a prominent cutaneous reaction, eosinophilia, hepatic abnormalities, and acute renal failure.

What drugs cause DRESS syndrome?

Medicines most commonly associated with DRESS syndrome are anticonvulsants, antibiotics (particularly beta-lactams), and allopurinol. Other medications that are known to be associated with DRESS include non-steroidal anti-inflammatory drugs, captopril, mood stabilisers, and antiretrovirals.

How do you treat DRESS syndrome?

Patients with DRESS, although optimum treatment remains controversial, are usually treated with corticosteroid [1, 2]. In individual cases, treatments with corticosteroids and intravenous immunoglobulin are reported to be effective; however, no controlled trials of such therapies are present.

What are the symptoms of DRESS syndrome?

Patients with DRESS can have a broad range of symptoms, which can include fever, rash, facial swelling, enlarged lymph nodes and kidney or liver injury. Most patients with DRESS will have an abnormal level of blood cells found in their blood tests, which are called eosinophils.

Can you recover from DRESS syndrome?

In addition, appropriate specialists should be consulted based on the affected organ systems. Most patients recover completely after drug withdrawal and appropriate therapy. However, some patients with DRESS syndrome suffer from chronic complications and approximately 10% die, primarily from visceral organ compromise.

Does DRESS syndrome go away?

Liver dysfunction in DRESS syndrome often lasts longer than in other severe cutaneous adverse drug reactions, and patients may improve anywhere from a few days in milder cases to months to achieve resolution of abnormalities. Severe hepatic involvement is thought to be the most notable cause of mortality.

Does DRESS syndrome go away on its own?

Who should not take allopurinol?

chronic heart failure. liver problems. moderate to severe kidney impairment. HLA-B *58:01 positive.

What happens if I stop taking allopurinol?

What will happen if I stop taking it? If you stop allopurinol treatment suddenly, there is a high risk that gout may get worse or you will get serious side effects. Only stop taking allopurinol if a doctor tells you to. A doctor will help you to reduce your dose slowly so you do not get serious side effects.

Can you get DRESS syndrome twice?

Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) may relapse following introduction of drugs structurally unrelated to the initial culprit drug.

What is allopurinol hypersensitivity syndrome? Over 60% of patients had received allopurinol for asymptomatic hyperuricemia. Hallmarks of this hypersensitivity syndrome include a prolonged illness initially manifested by fever, a prominent cutaneous reaction, eosinophilia, hepatic abnormalities, and acute renal failure. What drugs cause DRESS syndrome? Medicines most commonly associated with DRESS syndrome are anticonvulsants, antibiotics (particularly…