What are Aschoff giant cells?

In pathology, Aschoff cells (or Aschoff giant cells) are cells associated with rheumatic heart disease. They are found in Aschoff bodies surrounding centres of fibrinoid necrosis. In comparison with Anitschkow cells their cytoplasm is more basophilic and can contain up to four nuclei.

Why do you get subcutaneous nodules in rheumatic fever?

It is assumed that subcutaneous nodule (SCN), one of the major criteria in acute rheumatic fever (ARF), is rare and whenever these nodules appear, they are invariably associated with carditis.

What is the rheumatic heart disease?

Rheumatic heart disease is a condition in which the heart valves have been permanently damaged by rheumatic fever. Rheumatic fever is an inflammatory disease that can affect many connective tissues, especially in the heart. Untreated or under-treated strep infections put a person at increased risk.

Where are Aschoff bodies located?

They are especially found in the vicinity of small blood vessels in the myocardium and endocardium and occasionally in the pericardium, and also the adventitia of the proximal part of the aorta. Lesions similar to the Aschoff nodules may also be found in extra-cardiac tissues.

What is the name of the bacteria that causes acute rheumatic fever?

Acute rheumatic fever is a delayed sequela of pharyngitis due to Streptococcus pyogenes, which are also called group A Streptococcus or group A strep. The etiology, clinical features, diagnosis and treatment options, prognosis and complications, and prevention are described below.

Do rheumatic fever nodules go away?

The nodules are usually only found when severe carditis is present. They usually resolve within one month but may persist for longer.

Are subcutaneous nodules painful?

Abnormal bumps or masses (nodules) appear in the fatty layer under the skin (subcutaneous fat) of the legs, thighs and buttocks. In some patients, the arms, abdomen, and/or face may be involved. These nodules are usually 1-2 centimeters wide and may be either painful and tender or painless.

Where are Aschoff bodies found?

How do you say Verrucae?

noun, plural ver·ru·cae [vuh-roo-see, ve-].

What causes Aschoff nodules in the heart muscle?

Aschoff body. They result from inflammation in the heart muscle and are characteristic of rheumatic heart disease. These nodules were discovered independently by Ludwig Aschoff and Paul Rudolf Geipel, and for this reason they are occasionally called Aschoff-Geipel bodies .

Where are the Aschoff bodies found in the heart?

In medicine, Aschoff bodies are nodules found in the hearts of individuals with rheumatic fever. They result from inflammation in the heart muscle and are characteristic of rheumatic heart disease. These nodules were discovered independently by Ludwig Aschoff and Paul Rudolf Geipel, and for this reason they are…

How big are the nodules on the Aschoff body?

The nodule becomes oval or fusiform in shape about 200 micrometer x 600 micrometer in width and length. With passage of months and years the Aschoff nodules becomes less cellular and collagenous tissue is increased. Eventually it is replaced by a small fibrocollagenous scar with little cellularity frequently located perivascularly .

What does Asch off body mean in medical dictionary?

Asch·off body | \\ ˈä-ˌshȯf- \\. : one of the small nodules in heart muscle that are typical of rheumatic heart disease and consist of swollen collagen, cells, and fibrils. also : one of the similar but larger nodules found under the skin especially in rheumatic fever or polyarthritis. — called also Aschoff nodule.

What are Aschoff giant cells? In pathology, Aschoff cells (or Aschoff giant cells) are cells associated with rheumatic heart disease. They are found in Aschoff bodies surrounding centres of fibrinoid necrosis. In comparison with Anitschkow cells their cytoplasm is more basophilic and can contain up to four nuclei. Why do you get subcutaneous nodules in…