Why is acyclovir dosed on ideal weight?

Why is acyclovir dosed on ideal weight?

Acyclovir is a hydrophilic drug that is mainly distributed in the lean compartments of the body. Consequently, dosing on total body weight in obese patients may lead to drug overdosing.

What weight should I use for acyclovir?

Adults and children 12 years of age and older—Dose is based on body weight and must be determined by the doctor. The usual dose is 5 to 10 mg of acyclovir per kg (2.3 to 4.5 mg per pound) of body weight, injected slowly into a vein over at least a one-hour period, and repeated every eight hours for five to ten days.

When do you use adjusted weight vs ideal weight?

If a patient’s actual body weight was less than his or her ideal weight, then actual weight should be used. However, if the patient is obese, then a correction is used.

Does acyclovir make you sleepy?

Acyclovir oral tablet doesn’t cause drowsiness but it can cause other side effects.

Why does acyclovir not work for Covid 19?

“Coronaviruses are pretty tricky,” Seley-Radtke says. Simple nucleotide mimics like acyclovir won’t work, because these viruses have another protein that acts as an editor, monitoring the polymerase’s work, recognizing the decoy and cutting it out.

How do you calculate medication by weight?

The calculation is based on your weight in pounds (lb), and your daily mg dose of medication. Weight in pounds is converted to kilograms (kg) by dividing by 2

Can you take acyclovir on your body weight?

Dosing acyclovir on actual body weight (ABW) in obese patients may thus lead to supratherapeutic plasma concentrations because acyclovir distributes proportionally less in the excess fat tissue. The pharmacokinetics of acyclovir in obese patients has not been well studied.

What’s the maximum dose of acyclovir you can take in one day?

Less than 12 years: 20 to 25 mg/kg orally twice a day; Maximum dose: 400 mg 12 years or older: 200 mg orally 5 times a day for 5 days OR 800 mg orally 2 times a day for 5 days OR 800 mg orally 3 times a day for 2 days

How often should you take acyclovir for genital herpes?

Treatment of First Episode of Genital Herpes: 200 mg orally every 4 hours 5 times a day for 10 days (manufacturer dosing) 400 mg orally 3 times a day for 5 to 10 days (CDC recommendation) Severe Disease or Complications Requiring Hospitalization: 5 mg/kg IV every 8 hours for 5 days (manufacturer dosing)

How often should you take acyclovir for skin cancer?

400 mg orally 3 times a day for 5 to 10 days (guideline recommendation) Duration of therapy: 5 to 10 days-Severe Disease: 5 mg/kg IV every 8 hours after lesions begin to regress, may change to oral therapy; continue treatment until lesions have completely healed (guideline recommendation)

Why is acyclovir dosed on ideal weight? Acyclovir is a hydrophilic drug that is mainly distributed in the lean compartments of the body. Consequently, dosing on total body weight in obese patients may lead to drug overdosing. What weight should I use for acyclovir? Adults and children 12 years of age and older—Dose is based…