What is a hydrodynamically balanced system?
What is a hydrodynamically balanced system?
The ‘hydrodynamically balanced system’ (HBS) used for this novel dosage form of Madopar is a dosage form which, when in contact with gastric fluid and after dissolution of the gelatine shell of the capsule, forms a mucous body and a bulk density of less than 1 and releases the drug(s) at a desired rate whereas the …
Which system is also known as hydrodynamically balance system?
Which of the following is used to produce effervescence in floating drug delivery systems?
Effervescence floating drug delivery system means release of carbon dioxide gas due to reaction of acids and bicarbonates, e.g. of acids are citric acid, tartaric acid, and fumaric acid and e.g. of bicarbonate/carbonate are sodium bicarbonate, calcium carbonate, sodium carbonate and potassium carbonate.
Which drugs are suitable for Grdds?
Based on previously published literature, applications of gastroretentive drug delivery system (GRDDS) may be summarized for several categories of drugs (8) as drugs for local action in stomach, e.g., 5-flurouracil, antacids; drugs unstable in lower part of GIT, e.g., captopril; drugs insoluble in intestinal fluids ( …
What are types of floating DDS?
INTRODUCTION
| Types of dosage forms | Drugs explored in floating dosage forms | References |
|---|---|---|
| Granules | Diclofenac sodium, Indomethacin, Prednisolone. | [6,8] |
| Films | Cinnarizine, (capsules) | [8] |
| Capsules | Chlordiazepoxide HCl, Diazepam, Furocemide, L-Dopa and Benserazide, Misoprostol, Nicardipine, Propranolol HCl, Ursodeoxychoric acid | [6,8,10] |
What is the need for mucoadhesive systems?
Mucoadhesive drug delivery gives rapid absorption and good bioavailability due to its considerable surface area and high blood flow. Drug delivery across the mucosa bypasses the first-pass hepatic metabolism and avoiding the degradation of gastrointestinal enzymes.
What is the characteristics of mucoadhesive systems?
Other desired characteristics of a mucoadhesive dosage form include high drug loading capacity, controlled drug release (preferably unidirectional release), good mucoadhesive properties, smooth surface, tastelessness, and convenient application.
Which type of drug are not suitable for Grdds?
7 UNSUITABLE DRUGS FOR GRDDS 7 1] Drugs That Have Very Limited Acid Solubility E.g. Phenytoin, Etc. 2) Drugs That Suffer Instability In The Gastric Environment. E.g. Erythromycin, Etc. 3) Drugs Intended For Selective Release In The Colon E.g. 5-amino Salicylic Acid And Corticosteroids, Etc.
What are floating drug delivery systems?
Mechanism of Floating Systems: Floating drug delivery systems (FDDS) have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. After release of drug, the residual system is emptied from the stomach.
Are used in floating drug delivery system?
(A) Effervescent system floating drug delivery system sodium bicarbonate, tartaric acid, citric acid. These are formulated in such a specific way as once it comes in contact with gastric juice; co2 gets liberated with entrapment in swollen hydrocolloid to provide buoyancy for dosage form.
What are characteristics of mucoadhesive system?
Which is the hydrodynamically balanced form of Madopar?
The ‘hydrodynamically balanced system’ (HBS) used for this novel dosage form of Madopar is a dosage form which, when in contact with gastric fluid and after dissolution of the gelatine shell of the cap … Madopar HBS (125 mg) is a controlled-release dosage form with 100 mg L-dopa and 25 mg benserazide.
Why does hydrodynamic stability occur between two fluids?
The Rayleigh–Taylor instability is another application of hydrodynamic stability and also occurs between two fluids but this time the densities of the fluids are different. Due to the difference in densities, the two fluids will try to reduce their combined potential energy.
Who are some famous people who study hydrodynamic stability?
The foundations of hydrodynamic stability, both theoretical and experimental, were laid most notably by Helmholtz, Kelvin, Rayleigh and Reynolds during the nineteenth century. These foundations have given many useful tools to study hydrodynamic stability.
How is bifurcation theory used to study hydrodynamic stability?
Bifurcation theory is a useful way to study the stability of a given flow, with the changes that occur in the structure of a given system. Hydrodynamic stability is a series of differential equations and their solutions. A bifurcation occurs when a small change in the parameters of the system causes a qualitative change in its behavior,.
What is a hydrodynamically balanced system? The ‘hydrodynamically balanced system’ (HBS) used for this novel dosage form of Madopar is a dosage form which, when in contact with gastric fluid and after dissolution of the gelatine shell of the capsule, forms a mucous body and a bulk density of less than 1 and releases the…