What are the restenosis rates in patients with drug eluting stents?

High rates of in-stent restenosis (ISR) associated with bare-metal stents (BMSs) led to the development of drug-eluting stents (DESs), which modified the healing process after stent implantation, attenuating neointimal formation, and resulting in a reduction of the incidence of ISR to rates ranging from 5% to 10%.

How common is stent restenosis?

Ellis says, “in-stent restenosis still occurs in approximately 3 to 10% of patients within six to nine months, and sometimes afterwards. We have learned that restenosis is a very complex process.” Some known causes include: Stents that are too small or misaligned in the blood vessel.

How soon can restenosis occur after angioplasty?

Restenosis usually occurs within 3 to 6 months after angioplasty and stenting, and it is more likely to happen with bare metal stents than with drug-eluting stents. This is because drug-eluting stents are coated with a special drug that is released very slowly over time.

What causes instent restenosis?

Restenosis occurs as a result of the response of the vascular tissue to the injury caused by coronary angioplasty (7). In the case of in-stent restenosis, it is the result of vascular injury that occurs after stenting. The injury caused by insertion of a stent is different from the injury caused by angioplasty alone.

How long do drug eluting stents last?

Conclusions. Our study findings suggest that the long-term survival (to 3 years) of patients with drug-eluting stents remains favourable overall.

Can stents block up again?

What is Restenosis? Restenosis means that a section of blocked artery that was opened up with angioplasty or a stent has become narrowed again. There are many treatment options for patients who have restenosis after receiving a stent.

What is the prevalence of in stent restenosis?

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC. Despite on-going evolution and iteration of drug-eluting stent (DES) technology, the prevalence of in-stent restenosis (ISR) remains relatively unchanged, encompassing ≈10% of percutaneous coronary interventions.

What to do if you have restenosis after a stent?

Coronary artery bypass surgery is another option for people with stent restenosis, especially if the restenosis recurs after a second stent. Restenosis was originally the major limitation in using angioplasty and stents for coronary artery disease. As stent technology has improved, restenosis has now been greatly limited as a problem.

What’s the difference between restenosis and thrombosis?

Restenosis vs. Thrombosis. Stent thrombosis is usually a catastrophe, since it often produces sudden and complete blockage of the coronary artery. The risk of thrombosis is highest the first few weeks or months after stent placement, but is greatly reduced with the use of platelet-inhibiting drugs.

What are the current rates of stent thrombosis?

Current clinical registries and randomized trials with broad inclusion criteria show rates of ST at or <1% after 1 year and ∼0.2–0.4% per year thereafter; rates of clinical ISR are 5% respectively. Angiographic surveillance studies in large cohorts show rates of angiographic ISR of ∼10% with new-generation DES.

What are the restenosis rates in patients with drug eluting stents? High rates of in-stent restenosis (ISR) associated with bare-metal stents (BMSs) led to the development of drug-eluting stents (DESs), which modified the healing process after stent implantation, attenuating neointimal formation, and resulting in a reduction of the incidence of ISR to rates ranging from…