How do you calculate inhalation unit risk?

Note that the formula for the RSEI cancer/inhalation toxicity weight is expressed as Inhalation Unit Risk (risk per mg/m3)/ 2.8 x 10-7, where the denominator is simply the reciprocal of 3.5 (0.28) multiplied by the same arbitrary slope factor (1.0 x 10-6) used in the calculation for the cancer/oral toxicity weight.

What is RfC and RfD?

The inhalation chronic RfD is derived from an inhalation chronic reference concentration (RfC). Inhalation subchronic RfD–the RfD used with inhalation doses under subchronic exposures to estimate the potential of a systemic toxic effect. The inhalation subchronic RfD is derived from an inhalation subchronic RfC.

How do you interpret cancer slope factor?

Slope factors should always be accompanied by the weight of-evidence classification to indicate the strength of the evidence that the agent is a human carcinogen. B1 = indicates that limited human data are available. B2 = indicates sufficient evidence in animals and inadequate or no evidence in humans.

What is RfC EPA?

Reference Concentration (RfC): An estimate (with uncertainty spanning perhaps an order of magnitude) of a continuous inhalation exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime.

What is a toxicity value?

A toxicity reference value (TRV) is a toxicological index that, when compared with exposure, is used to qualify or quantify a risk to human health.

What is the uncertainty factor?

Uncertainty factors are used to compensate for a deficiency in knowledge concerning the accuracy of test results and the difficulty in estimating the health effects in a different species and/or in different exposure conditions.

What does RFC mean in project management?

Request for Change
Definition: The Request for Change (RFC) is formal request for the implementation of a Change. The RFC is a precursor to the ‘Change Record’ and contains all information required to approve a Change. Further information is added as the Change progresses through its lifecycle.

How do you calculate carcinogenic risk?

For carcinogenicity, the probability of an individual developing cancer over a lifetime is estimated by multiplying the cancer slope factor (mg/kg/day) for the substance by the chronic (70-year average) daily intake (mg/kg-day).

What is chronic daily intake CDI )?

Chronic Daily Intake (CDI). Exposure expressed as mass of a substance contacted per unit body weight per unit time, averaged over a long period of time (as a Superfund program guideline, seven years to a lifetime).

What is slope factor EPA?

The slope factor is the cancer risk (proportion affected) per unit of dose. In the IRIS chemical files the slope factor is expressed on the basis of chemical weight [milligrams of substance per kilogram body weight per day (mg/kg/day)].

What is RfD in toxicology?

A reference dose (RfD) is defined as an estimate of a daily exposure to the human population (including sensitive subpopulations) that is likely to be without an appreciable risk of deleterious effects during a lifetime. From: Encyclopedia of Toxicology (Second Edition), 2005.

How is the RFC calculated for acute inhalation?

Assessment of RfC for acute inhalation exposure is based on a human study ( n =26 subjects) with a ‘tentative’ NOAEL of 262 mg/m 3. The calculated RfC for 1 h exposure is 104.8 mg/m 3. The RfC is given a low confidence rating as there was only one methanol concentration used.

Where does the inhalation chronic RfD come from?

What does a reference concentration ( RFC ) mean?

Which is the reference dose for a toxic response?

Reference Dose (RfD) –for those chemicals eliciting a toxic response, the oral chronic RfD, dermal chronic RfD, oral subchronic RfD, dermal subchronic RfD, inhalation chronic RfD, inhalation chronic RfD, and inhalation subchronic RfD are provided.

How do you calculate inhalation unit risk? Note that the formula for the RSEI cancer/inhalation toxicity weight is expressed as Inhalation Unit Risk (risk per mg/m3)/ 2.8 x 10-7, where the denominator is simply the reciprocal of 3.5 (0.28) multiplied by the same arbitrary slope factor (1.0 x 10-6) used in the calculation for the…